Funded by Yorkshire Cancer Research the North of England Women’s Diet and ActivitY After Breast Cancer Trial (NEWDAY-ABC) is a weight management intervention for overweight/obese women recovering from early-stage estrogen-receptor positive (ER+ve) breast cancer treatment. Excess body weight is associated with poorer ER+ve breast cancer survival outcomes however; previous lifestyle interventions have frequently failed to produce clinically-important weight loss in this population. Led by Professor John Saxton (Northumbria University, Newcastle) and Dr Caroline Wilson (Weston Park Hospital, Sheffield), in collaboration with Sheffield Hallam University, the intervention was co-designed with 16 BCsurvivors and 21 HCPs from three NHS trusts in South Yorkshire and North East England. Addressing the perceived challenges of weight loss (and maintenance) by building breast cancer-survivors’ skills and confidence to engage in sustainable physical activity (PA) and healthy eating, a multi-centre randomised controlled trial, with internal pilot, will test the clinical and cost-effectiveness via the following outcome measures over a 12 monthtimeframe: Primary Outcomes: Body weight and health-related quality of life. Secondary Outcomes: Body composition (DEXA); stature, waist and hip girth; blood pressure; eating habits and alcohol intake (AUDIT-C); 7-day physical activity data (accelerometry & self-report); body image; fear of cancer recurrence; fatigue (FACIT) blood markers associated with cancer recurrence/cardiometabolic risk; and a health economic evaluation. The co-design phase began in June 2018 and the internal pilot is due to open in February 2020 and complete in October 2020 with data available December 2020.
Dr Katie Pickering; Sheffield Hallam University